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boltz Plugin

Author
Boltz
Category
Development
Topics
AI Agents & AI App Development · Web Search, Research & Learning · Claude Code Customization & Workflow
First seen
2026-07-09
Last confirmed
2026-07-13
Explanation last updated
2026-07-12

The explanation below is AI-generated. Please verify it against the sources.

The boltz plugin lets you run Boltz's biomolecular AI workflows directly from Claude Code by describing tasks in natural language, which the agent translates into calls to the boltz-api CLI. According to the README, it supports structure prediction with optional binding-affinity scoring, screening of small-molecule (SMILES) and protein/antibody libraries against a target, de novo design of small-molecule and protein binders, Tier-1 ADME estimation, and job status tracking. Using it requires the boltz-api CLI to be installed on PATH and authenticated via device-code login or an API key, and job results are downloaded to a boltz-experiments/ directory. The README states that before a job is submitted, the agent shows a cost estimate. Boltz itself is described on its homepage as a research lab building frontier generative AI models for biology and chemistry, offered through the Boltz API platform.

Overview

According to the boltz.bio homepage, Boltz is an AI platform/API for biomolecular modeling that offers models such as BoltzMol-1, BoltzProt-1, Boltz-2, and BoltzGen for designing small molecules and proteins, predicting structures, and screening candidates, with multi-tenant, single-tenant, or on-premise deployment and SOC 2 Type 1 verification. This Claude Code plugin exposes those capabilities as a set of "skills" that call the boltz-api CLI from within an agent session.

What you can do with boltz

  • Predict the 3D structure of a protein–ligand or other complex and optionally score binding affinity (boltz-structure-and-binding)
  • Rank a SMILES library against a target (boltz-small-molecule-screen)
  • Generate novel small-molecule binders (boltz-small-molecule-design)
  • Estimate Tier-1 ADME properties (solubility, permeability, logD) from bare SMILES (boltz-small-molecule-adme)
  • Rank proteins, peptides, or antibodies against a target (boltz-protein-screen)
  • Generate novel peptide, antibody, nanobody, or custom-protein binders (boltz-protein-design)
  • Install, update, verify, and authenticate the boltz-api CLI (boltz-cli-setup)
  • List and inspect jobs, and recover results after an interrupted session (boltz-check-status)

Sources

Original description (English)

Predict structures, screen molecules and proteins, and design binders with Boltz from Claude Code.

History of boltz

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