boltz Claude Code Plugin
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The boltz plugin lets Claude Code run Boltz's biomolecular modeling workflows, including 3D structure prediction, binding affinity scoring, small-molecule and protein screening, and de novo binder design. It operates by invoking the boltz-api command-line tool, which must be installed separately and authenticated using either a device-code login or an API key. The plugin bundles eight skills covering CLI setup, structure-and-binding prediction, small-molecule and protein screening, small-molecule ADME estimation, small-molecule and protein design, and job-status checking. After a job is submitted and completed, results are downloaded automatically into a local boltz-experiments folder. The underlying service is the Boltz API, a hosted platform for biomolecular AI models operated by Boltz PBC.
About the service
Boltz API is a cloud service operated by Boltz PBC that hosts AI models for predicting biomolecular structures, screening small molecules and proteins, and designing new binder molecules. According to the Boltz homepage, it supports multi-tenant, single-tenant, and on-premise deployment options.
What you can do with boltz
- Predict the 3D structure of a protein–ligand or other biomolecular complex, optionally scoring binding affinity
- Rank a list of SMILES compounds against a chosen target
- Estimate basic ADME properties (solubility, permeability, logD) from bare SMILES
- Rank candidate proteins, peptides, or antibodies against a target
- Generate novel small-molecule or protein binders, including peptides, antibodies, nanobodies, or custom proteins
- Install, update, and authenticate the boltz-api command-line tool
- List submitted jobs and recover results after an interrupted session